伪-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPAR纬 Pathways in High-Fat Diet-Induced Obese Mice

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• 作者：Young Hee Choi ; Jin Kyung Bae ; Hee-Sung Chae ; Young-Mi Kim ; Yim Sreymom ; Ling Han ; Ha Young Jang ; Young-Won Chin
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：September 30, 2015
• 年：2015
• 卷：63
• 期：38
• 页码：8399-8406
• 全文大小：525K
• ISSN：1520-5118

文摘

Previous studies have shown that 伪-mangostin (伪-MG) suppresses intracellular fat accumulation and stimulation of lipolysis in in vitro systems. Together with the relatively high distribution of 伪-MG in liver and fat, these observations made it possible to propose a plausible hypothesis that an 伪-MG supplement may regulate hepatic steatosis and obesity. An 伪-MG supplement (50 mg/kg) reduced the body weight gain (13.8%) and epidymal and retroperitoneal fat mass accumulation (15.0 and 11.3%, respectively), as well as the biochemical serum profiles such as cholesterol [TC (26.9%), LDL-C (39.1%), and HDL-C (15.3%)], glucose (30.2%), triglyceride (29.7%), and fatty acid (30.3%) levels in high-fat fed mice compared with the high-fat diet-treated group, indicating that 伪-MG may regulate lipid metabolism. In addition, an 伪-MG supplement up-regulated hepatic AMPK, SirT1, and PPAR纬 levels compared with the high-fat diet states, suggesting that 伪-MG regulates hepatic steatosis and obesity through the SirT1-AMPK and PPAR纬 pathways in high-fat diet-induced obese mice.