Concise and Enantioselective Total Synthesis of 15-Deoxy-Δ12,14-Prostaglandin J2

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• 作者：Nam-Jung Kim ; Hyunyoung Moon ; Taesun Park ; Hwayoung Yun ; Jong-Wha Jung ; Dong-Jo Chang ; Dae-Duk Kim ; Young-Ger Suh
• 刊名：Journal of Organic Chemistry
• 出版年：2010
• 出版时间：November 5, 2010
• 年：2010
• 卷：75
• 期：21
• 页码：7458-7460
• 全文大小：686K
• 年卷期：v.75,no.21(November 5, 2010)
• ISSN：1520-6904

文摘

The concise and enantioselective synthesis of 15-deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂) has been accomplished in 11 steps from a known alcohol. The key step of the synthesis involves an asymmetric Rh-catalyzed cycloisomerization of ene-ynone, followed by an olefin isomerization.