Red Emissive Two-Photon Probe for Real-Time Imaging of Mitochondria Trafficking

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• 作者：Avik R. Sarkar ; Cheol Ho Heo ; Hyo Won Lee ; Kyung Hee Park ; Young Ho Suh ; Hwan Myung Kim
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：June 17, 2014
• 年：2014
• 卷：86
• 期：12
• 页码：5638-5641
• 全文大小：277K
• 年卷期：v.86,no.12(June 17, 2014)
• ISSN：1520-6882

文摘

Mitochondria trafficking plays an essential role for supplying energy in the neuronal system. We report here a red emissive two-photon probe for mitochondria (CMT-red) that showed high selectivity and robust staining ability for mitochondria, high photostability under a two-photon microscopy imaging condition, and low cytotoxicity. This probe can be easily loaded into live cells and tissue and used for real-time, high resolution imaging of the mitochondria trafficking in primary cortical neurons as well as in rat hippocampal tissue.