Multilayered Nanoparticles for Controlled Release of Paclitaxel Formed by Near-Critical Micellization of Triblock Copolymers

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• 作者：Zachary L. Tyrrell ; Youqing Shen ; Maciej Radosz
• 刊名：Macromolecules
• 出版年：2012
• 出版时间：June 12, 2012
• 年：2012
• 卷：45
• 期：11
• 页码：4809-4817
• 全文大小：391K
• 年卷期：v.45,no.11(June 12, 2012)
• ISSN：1520-5835

文摘

Near-critical micellization (NCM), allowing for precise pressure-tuned control of sequential block collapse and micelle formation, can be synchronized with cancer-drug encapsulation with virtually no drug losses. NCM is demonstrated to produce benign, stable nanoparticles made of PEG-b-PLLA-b-PCL triblock copolymers that are not only solvent-free and paclitaxel-rich, which reduces the body exposure to the excipients, but also nearly burst-release-free, which reduces if not eliminates its toxic side effects while enhancing its therapeutic efficacy.