Palladium-Catalyzed Synthesis of 3-Acylated Indoles Involving Oxidative Cross-Coupling of Indoles with 伪-Amino Carbonyl Compounds

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• 作者：Ri-Yuan Tang ; Xiao-Kang Guo ; Jian-Nan Xiang ; Jin-Heng Li
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：November 15, 2013
• 年：2013
• 卷：78
• 期：22
• 页码：11163-11171
• 全文大小：482K
• 年卷期：v.78,no.22(November 15, 2013)
• ISSN：1520-6904

文摘

A new and selective C鈥揘 bond oxidative cleavage method to 3-acylated indoles by Pd-catalyzed oxidative cross coupling of indoles with 伪-amino carbonyl compounds has been developed; moreover, one-pot synthesis of 3-acylated indoles from 2-ethynylanilines and 伪-amino carbonyl compounds has also been established. Importantly, the products 3-acylated indoles can be used to construct polyheterocyclic compound, which can be employed as efficient probes for Hg²⁺ and Fe³⁺.