Rh(III)-Catalyzed [4 + 2] Annulation of Indoles with Diazo Compounds: Access to Pyrimido[1,6-a]indole-1(2H)-ones

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• 作者：Xun Chen ; Xinwei Hu ; Siyi Bai ; Yuanfu Deng ; Huanfeng Jiang ; Wei Zeng
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：January 15, 2016
• 年：2016
• 卷：18
• 期：2
• 页码：192-195
• 全文大小：410K
• ISSN：1523-7052

文摘

The Rh(III)-catalyzed regioselective C2–H bond carbenoid insertion/cyclization of N-amidoindoles with α-acyl diazo compounds has been developed. This method provides a novel approach to 2H-pyrimido[1,6-a]indol-1-ones with a broad range of functional group tolerance. The synthetic utilities of the approach are demonstrated by versatile chemical transformations.