A Neuroprotective Polysaccharide from Hyriopsis cumingii

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• 作者：Changfeng Hu ; Jinhui Li ; Deyu Yang ; Yuanjiang Pan ; Haitong Wan
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：September 24, 2010
• 年：2010
• 卷：73
• 期：9
• 页码：1489-1493
• 全文大小：129K
• 年卷期：v.73,no.9(September 24, 2010)
• ISSN：1520-6025

文摘

A water-soluble polysaccharide from Hyriopsis cumingii (HCp) was isolated by hot-water extraction and ethanol precipitation. We investigated the preliminary neuroprotective activity of HCp on cerebral ischemia/reperfusion (I/R)-induced rat brain tissue injury using the middle cerebral artery occlusion (MCAO) model. The structural analysis showed that the major component of HCp (HP-I) is an α-(1→4)-d-glucan branched with a single α-d-glucose at C-6 every five residues on average and has a weight-average molecular weight of about 2.65 × 10⁵. Pharmacological studies revealed that HCp improves and restores nerve function impairment, significantly increases brain tissue total superoxide dismutase activity, lowers malondialdehyde content effectively, and reduces brain levels of caspase-3 mRNA expression in a dose−effect manner, indicating that H. cumingii polysaccharide possesses significant neuroprotective effects.