Supramolecular Fluorescent Nanoparticles for Targeted Cancer Imaging
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- 作者：Ruijiao Dong ; Hongying Chen ; Dali Wang ; Yuanyuan Zhuang ; Lijuan Zhu ; Yue Su ; Deyue Yan ; Xinyuan Zhu
- 刊名：ACS Macro Letters
- 出版年：2012
- 出版时间：October 16, 2012
- 年：2012
- 卷：1
- 期：10
- 页码：1208-1211
- 全文大小：281K
- 年卷期：v.1,no.10(October 16, 2012)
- ISSN：2161-1653
文摘
By a combination of excellent fluorescent performance with smart targeting capability for cancer-specific delivery, a promising class of calcein-based supramolecular fluorescent nanoparticles has been successfully prepared via a 鈥渂ricks and mortar鈥?strategy. Through tuning the molar ratio of adamantane-functionalized calcein (CA-AD)/尾-cyclodextrin-grafted branched polyethylenimine (PEI-CD), the size of these fluorescent nanoparticles can be effectively controlled. Importantly, the 尾-cyclodextrin/adamantane (尾-CD/AD = 1/1) host鈥揼uest interaction dramatically suppresses the 蟺鈥撓€ stacking and fluorescence self-quenching of calcein chromophores in water, leading to the formation of highly fluorescent nanoparticles. By introduction of the folate receptor, these fluorescent nanoparticles exhibit excellent cancer imaging efficiency.