Tandem Reaction of 1-Copper(I) Alkynes for the Synthesis of 1,4,5-Trisubstituted 5-Chloro-1,2,3-triazoles
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- 作者：Bo Wang ; Jianlan Zhang ; Xinyan Wang ; Nan Liu ; Wenwen Chen ; Yuefei Hu
- 刊名：Journal of Organic Chemistry
- 出版年：2013
- 出版时间：October 18, 2013
- 年：2013
- 卷：78
- 期：20
- 页码：10519-10523
- 全文大小：312K
- 年卷期：v.78,no.20(October 18, 2013)
- ISSN：1520-6904
文摘
A novel tandem reaction of 1-copper(I) alkynes with azides (cycloaddition) and then NCS (electrophilic substitution) was developed as an efficient method for the synthesis of 1,4,5-trisubstituted 5-chloro-1,2,3-triazoles. The method offers a rare example that a tandem reaction of an organometallic substrate does not involve in the reactivity of the metal鈥揷arbon bond in the first step.