Copper-Catalyzed N-Methylation of Amides and O-Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents

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• 作者：Qinqin Xia ; Xiaolong Liu ; Yuejiao Zhang ; Chao Chen ; Wanzhi Chen
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 5, 2013
• 年：2013
• 卷：15
• 期：13
• 页码：3326-3329
• 全文大小：288K
• 年卷期：v.15,no.13(July 5, 2013)
• ISSN：1523-7052

文摘

The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.