Controlled Assembly and Release of Retinoic Acid Based on the Layer-by-Layer Method

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• 作者：Yueyue Chen ; Guanghong Zeng ; Fei Pan ; Junbo Wang ; Lifeng Chi
• 刊名：Langmuir
• 出版年：2013
• 出版时间：February 26, 2013
• 年：2013
• 卷：29
• 期：8
• 页码：2708-2712
• 全文大小：346K
• 年卷期：v.29,no.8(February 26, 2013)
• ISSN：1520-5827

文摘

All-trans retinoic acid (RA) has been proved to play important roles in regulating cell growth in various types of cells. Yet most experiments were performed by adding RA in solution previously. In this Article, we focus on the incorporation of RA, as a negatively charged moiety, into layered polyelectrolyte films on surfaces by means of layer-by-layer (LbL) deposition, followed by adding of capping layers to regulate the release of RA from the films. The incorporated RA was designed to release over 5 days in buffer solution. The assembly and release of RA were verified by UV and QCM results. The controlled release of RA from multilayer films can serve as a model system to study the influence of small molecules on cell growth.