Regio- and Enantioselective Baeyer鈥揤illiger Oxidation: Kinetic Resolution of Racemic 2-Substituted Cyclopentanones

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• 作者：Lin Zhou ; Xiaohua Liu ; Jie Ji ; Yuheng Zhang ; Wangbin Wu ; Yangbin Liu ; Lili Lin ; Xiaoming Feng
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：3938-3941
• 全文大小：333K
• ISSN：1523-7052

文摘

A kinetic resolution of racemic 2-substituted cyclopentanones via highly regio- and enantioselective Baeyer鈥揤illiger oxidation has been successfully developed. The reaction could afford the normal 6-substituted 未-lactones in up to 98% ee and >19/1 regioselectivity. Meanwhile, the unreacted ketones were recovered in excellent ee values (up to 98%). It represents the best results of the kinetic resolution of racemic 2-substituted cyclopentanones via nonenzymic asymmetric BV oxidation.