Benzylphenethylamine Alkaloids from Hosta plantaginea with Inhibitory Activity against Tobacco Mosaic Virus and Acetylcholinesterase

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• 作者：Yue-Hu Wang ; Zhong-Kai Zhang ; Fu-Mei Yang ; Qian-Yun Sun ; Hong-Ping He ; Ying-Tong Di ; Shu-Zhen Mu ; Yang Lu ; Ying Chang ; Qi-Tai Zheng ; Ming Ding ; Jia-Hong Dong ; Xiao-Jiang Hao
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：70
• 期：9
• 页码：1458 - 1461
• 全文大小：95K
• 年卷期：v.70,no.9(September 2007)
• ISSN：1520-6025

文摘

Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasine, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC₅₀ = 1.80 µM), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC₅₀ of 2.32 µM.