N-Heterocyclic Carbene (NHC)-Catalyzed Highly Diastereo- and Enantioselective Oxo-Diels鈥揂lder Reactions for Synthesis of Fused Pyrano[2,3-b]indoles
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- 作者：Limin Yang ; Fei Wang ; Pei Juan Chua ; Yunbo Lv ; Liang-Jun Zhong ; Guofu Zhong
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：June 1, 2012
- 年：2012
- 卷：14
- 期：11
- 页码：2894-2897
- 全文大小：237K
- 年卷期：v.14,no.11(June 1, 2012)
- ISSN：1523-7052
文摘
A chiral N-heterocyclic carbene (NHC)-catalyzed Diels鈥揂lder reaction of 2-oxoindolin-3-ylidenes and 伪-chloroaldehydes was developed for the synthesis of fused pyrano[2,3-b]indoles in good to excellent yields (up to 99%) with high cis-diastereoselectivities (>99:1 dr) and enantioselectivities (up to >99% ee).