Asymmetric 伪-Photoalkylation of 尾-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters

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• 作者：Yunbo Zhu ; Long Zhang ; Sanzhong Luo
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：October 22, 2014
• 年：2014
• 卷：136
• 期：42
• 页码：14642-14645
• 全文大小：391K
• ISSN：1520-5126

文摘

We describe the direct construction of all-carbon quaternary stereocenters via 伪-photoalkylation of 尾-ketocarbonyls with high efficacy and enantioselectivities by merging photoredox catalysis and primary amine catalysis. The open-shell photoradical approach enables asymmetric 伪-alkylations that are difficult under thermal conditions.