Construction of 1,4-Benzodiazepine Skeleton from 2-(Arylamino)benzamides through PhI(OAc)2-Mediated Oxidative C–N Bond Formation
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- 作者：Xuming Li ; Liu Yang ; Xiang Zhang ; Daisy Zhang-Negrerie ; Yunfei Du ; Kang Zhao
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：February 7, 2014
- 年：2014
- 卷：79
- 期：3
- 页码：955-962
- 全文大小：416K
- ISSN：1520-6904
文摘
New compounds involving the biologically important 1,4-benzodiazepine skeleton were conveniently constructed from 2-(arylamino)benzamides through PhI(OAc)2-mediated oxidative C鈥揘 bond formation. The attractive features of this new synthetic strategy include mild reaction conditions, the heavy-metal-free characteristic of the oxidative coupling process, and the flexibility to tolerate a broad scope of substrates.