Palladium-Catalyzed Direct Arylation of Indoles with Cyclohexanones

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• 作者：Shanping Chen ; Yunfeng Liao ; Feng Zhao ; Hongrui Qi ; Saiwen Liu ; Guo-Jun Deng
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1618-1621
• 全文大小：291K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.