Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum

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• 作者：Yungen Liu ; Chun-Nam Lok ; Ben Chi-Bun Ko ; Tina Yuen-Ting Shum ; Man-Kin Wong ; Chi-Ming Che
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：April 2, 2010
• 年：2010
• 卷：12
• 期：7
• 页码：1420-1423
• 全文大小：267K
• 年卷期：v.12,no.7(April 2, 2010)
• ISSN：1523-7052

文摘

A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.