p-Toluenesulfonohydrazide as Highly Efficient Initiator for Direct C鈥揌 Arylation of Unactivated Arenes

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• 作者：Qiao Song ; Dongmei Zhang ; Qihua Zhu ; Yungen Xu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：October 17, 2014
• 年：2014
• 卷：16
• 期：20
• 页码：5272-5274
• 全文大小：216K
• ISSN：1523-7052

文摘

p-Toluenesulfonohydrazide (PTSH) was shown to promote the highly efficient direct arylation of unactivated arenes with aryl iodides, bromides, or chlorides in the presence of potassium tert-butoxide without the assistance of any transition metals. The reaction proceeds through base-promoted homolytic aromatic substitution (BHAS) involving aryl radicals and arylradical anions as intermediates.