Biocompatible 3D Liquid Crystal Elastomer Cell Scaffolds and Foams with Primary and Secondary Porous Architecture
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- 作者：Yunxiang Gao ; Taizo Mori ; Sarah Manning ; Yu Zhao ; Alek d. Nielsen ; Abdollah Neshat ; Anshul Sharma ; Cory J. Mahnen ; Heather R. Everson ; Sierra Crotty ; Robert J. Clements ; Christopher Malcuit ; E. Hegmann
- 刊名：ACS Macro Letters
- 出版年：2016
- 出版时间：January 19, 2016
- 年：2016
- 卷：5
- 期：1
- 页码：4-9
- 全文大小：419K
- ISSN：2161-1653
文摘
3D biodegradable and highly regular foamlike cell scaffolds based on biocompatible side-chain liquid crystal elastomers have been prepared. Scaffolds with a primary porosity characterized by spatially interlaced, interconnected microchannels or an additional secondary porosity featuring interconnected microchannel networks define the novel elastomeric scaffolds. The macroscale morphology of the dual porosity 3D scaffold resembles vascular networks observed in tissue. 3D elastomer foams show four times higher cell proliferation capability compared to conventional porous templated films and within the channels guide spontaneous cell alignment enabling the possibility of tissue construct fabrication toward more clinically complex environments.