One-Pot Synthesis of N-(伪-Peroxy)Indole/Carbazole via Chemoselective Three-Component Condensation Reaction in Open Atmosphere

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• 作者：Xinbo Wang ; Yupeng Pan ; Kuo-Wei Huang ; Zhiping Lai
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：17
• 期：22
• 页码：5630-5633
• 全文大小：365K
• ISSN：1523-7052

文摘

A facile one-pot synthesis of N-(伪-peroxy)indole and N-(伪-peroxy)carbazole has been developed using metal-free, organo-acid-catalyzed three-component condensation reactions of indole/carbazole, aldehyde, and peroxide. Based on the reaction discovered, a new synthetic proposal for Fumitremorgin A and Verruculogen is introduced. Such a protocol could be easily handled and scaled up in an open atmosphere with a wide substrate scope, enabling the construction of a new molecule library.