Bioactive neo-Clerodane Diterpenoids from the Whole Plants of Ajuga ciliata Bunge

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• 作者：Ping Guo ; Yushan Li ; Jing Xu ; Cuizhou Liu ; Yonggang Ma ; Yuanqiang Guo
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：July 22, 2011
• 年：2011
• 卷：74
• 期：7
• 页码：1575-1583
• 全文大小：886K
• 年卷期：v.74,no.7(July 22, 2011)
• ISSN：1520-6025

文摘

Ten new neo-clerodane diterpenes, ajugaciliatins A鈥揓 (1鈥?b>5, 8鈥?b>12), along with 17 known analogues (6, 7, 13鈥?b>27) were isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the configuration of 1 was confirmed by X-ray crystallography. All of the compounds were assessed for neuroprotective effects against MPP⁺-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells. Compounds 2, 6, 7, 9, 10, 15鈥?b>17, 19, and 20 exhibited moderate neuroprotective effects.