Copper-Catalyzed Direct Oxidative C鈥揌 Amination of Benzoxazoles with Formamides or Secondary Amines under Mild Conditions

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• 作者：Yaming Li ; Yusheng Xie ; Rong Zhang ; Kun Jin ; Xiuna Wang ; Chunying Duan
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：July 1, 2011
• 年：2011
• 卷：76
• 期：13
• 页码：5444-5449
• 全文大小：885K
• 年卷期：v.76,no.13(July 1, 2011)
• ISSN：1520-6904

文摘

A facile, efficient, and practical method for copper-catalyzed direct C鈥揌 amination of benzoxazoles with formamides or secondary amines has been developed. The system can be performed in the absence of external base and only requires O₂ or even air as oxidant. A variety of substituted benzoxazol-2-amines were synthesized with moderate to excellent yield.