Construction of Spiro-Fused 2-Oxindole/伪-Methylene- 纬-Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N-Methyl Isatin
详细信息 查看全文
- 作者：Yusuke Murata ; Masaki Takahashi ; Fumitoshi Yagishita ; Masami Sakamoto ; Tetsuya Sengoku ; Hidemi Yoda
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：December 20, 2013
- 年：2013
- 卷：15
- 期：24
- 页码：6182-6185
- 全文大小：227K
- 年卷期：v.15,no.24(December 20, 2013)
- ISSN：1523-7052
文摘
A remarkably effective method allowing an extremely high enantioselective synthesis of the spiro-fused 2-oxindole/伪-methylene-纬-butyrolactones is described. The key strategy lies in the use of indium-catalyzed asymmetric amide allylation of N-methyl isatin with functionalized allylstannanes, which can lead to the antineoplastic spirocyclic lactones in almost enantiopure forms.