Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides

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• 作者：Saqib Faisal ; Pradip K. Maity ; Qin Zang ; Thiwanka B. Samarakoon ; Robert L. Sourk ; Paul R. Hanson
• 刊名：ACS Combinatorial Science
• 出版年：2016
• 出版时间：July 11, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：387-393
• 全文大小：542K
• 年卷期：0
• ISSN：2156-8944

文摘

Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular S_NAr, alkylation with silica-supported oligomeric benzyl (Si-OBP_n) and triazole (Si-OTP_n) phosphates, and intermolecular S_NAr addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields.