Transition-Metal-Mediated Three-Component Cascade Cyclization: Selective Cage B鈥揅(sp2) Coupling of Carborane with Aromatics and Synthesis of Carborane-Fused Tricyclics
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- 作者：Yangjian Quan ; Zaozao Qiu ; Zuowei Xie
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：May 28, 2014
- 年：2014
- 卷：136
- 期：21
- 页码：7599-7602
- 全文大小：297K
- 年卷期：v.136,no.21(May 28, 2014)
- ISSN：1520-5126
文摘
Zirconium/nickel comediated one-pot three-component cascade cyclization of carboryne, alkene, and 2-bromophenyltrimethylsilylacetylene has been achieved, leading to the formation of a series of C,C,B-substituted carborane-fused tricyclics. On the basis of experimental results, a plausible mechanism is proposed including [2 + 2 + 1] cross-cyclotrimerization followed by intramolecular direct selective cage B鈥揅(sp2) coupling. This represents the first example of direct cage B鈥揅(phenyl) coupling via cage B鈥揌 activation.