2,2,2-Trifluoroethyl Chlorooxoacetate鈥擴niversal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides
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- 作者：Andrey V. Bogolubsky ; Yurii S. Moroz ; Pavel K. Mykhailiuk ; Sergey E. Pipko ; Anton V. Zhemera ; Anzhelika I. Konovets ; Olena O. Stepaniuk ; Inna S. Myronchuk ; Yurii V. Dmytriv ; Roman A. Doroschuk ; Olga A. Zaporozhets ; Andrey Tolmachev
- 刊名：ACS Combinatorial Science
- 出版年：2015
- 出版时间：October 12, 2015
- 年：2015
- 卷：17
- 期：10
- 页码：615-622
- 全文大小：514K
- ISSN：2156-8944
文摘
A one-pot parallel synthesis of N1-aryl-N2-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.