A Mixed-Crystal Lanthanide Zeolite-like Metal鈥揙rganic Framework as a Fluorescent Indicator for Lysophosphatidic Acid, a Cancer Biomarker

详细信息    查看全文

• 作者：Shi-Yuan Zhang ; Wei Shi ; Peng Cheng ; Michael J. Zaworotko
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：September 30, 2015
• 年：2015
• 卷：137
• 期：38
• 页码：12203-12206
• 全文大小：356K
• ISSN：1520-5126

文摘

Two lanthanide zeolite-like metal鈥搊rganic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb³⁺ and Eu³⁺ ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4鈥?3.3 渭M). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.