Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals

详细信息    查看全文

• 作者：Brian M. Zeglis ; Jacob L. Houghton ; Michael J. Evans ; Nerissa Viola-Villegas ; Jason S. Lewis
• 刊名：Inorganic Chemistry
• 出版年：2014
• 出版时间：February 17, 2014
• 年：2014
• 卷：53
• 期：4
• 页码：1880-1899
• 全文大小：700K
• ISSN：1520-510X

文摘

Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: ⁶⁴Cu-ATSM, ⁶⁸Ga-DOTATOC, ⁸⁹Zr-transferrin, ^99mTc-sestamibi, and ^99mTc-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.