Three-Component Assembly of Conjugated Enyne Scaffolds via E-Selective Olefination of Ynals

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• 作者：Dong Cheng ; Fei Ling ; Zexiang Li ; Weijun Yao ; Cheng Ma
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：14
• 期：12
• 页码：3146-3149
• 全文大小：241K
• 年卷期：v.14,no.12(June 15, 2012)
• ISSN：1523-7052

文摘

Benefited by the accessible ynamido鈥搇ithium intermediates Ib from a Cu-catalyzed azide鈥揳lkyne cycloaddition in the presence of stoichiometric amounts of LiOH, a mild and flexible three-component route to conjugated enyne scaffolds was successfully achieved via a formal E-selective olefination strategy.