Mild Cu(I)-Catalyzed Cascade Reaction of Cyclic Diaryliodoniums, Sodium Azide, and Alkynes: Efficient Synthesis of Triazolophenanthridines

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• 作者：Zhenquan Liu ; Daqian Zhu ; Bingling Luo ; Naiyuan Zhang ; Qi Liu ; Yumin Hu ; Rongbiao Pi ; Peng Huang ; Shijun Wen
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5600-5603
• 全文大小：342K
• ISSN：1523-7052

文摘

Linear iodoniums are widely used as arylating reagents. However, cyclic diaryl idodoniums are ignored despite their potential to initiate dual arylations, atom and step economically. In our current work, a three-component cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes has been successfully achieved under mild conditions, catalyzed by cheap copper species. The regioselectivity associated with unsymmetrical iodoniums was enhanced by installing two methyls ortho and para to the I^III center. The reaction enables a rapid access to a variety of complex molecules, triazolophenanthridine derivatives.