Bioactive Bibenzyl Derivatives and Fluorenones from Dendrobium nobile

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• 作者：Xue Zhang ; Jie-Kun Xu ; Jue Wang ; Nai-Li Wang ; Hiroshi Kurihara ; Sumumu Kitanaka ; Xin-Sheng Yao
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：January 2007
• 年：2007
• 卷：70
• 期：1
• 页码：24 - 28
• 全文大小：68K
• 年卷期：v.70,no.1(January 2007)
• ISSN：1520-6025

文摘

Bioassay-guided fractionation of the 60% ethanol extract of the stems of Dendrobium nobile using the DPPH assay ledto the isolation of two new bibenzyl derivatives, nobilin D (1) and nobilin E (2), and a new fluorenone, nobilone (3),together with seven known compounds (4-10). Their structures were determined on the basis of spectroscopic analyses.Compounds 1, 2, 4, 7, 8, and 10 exhibited significant antioxidant activity higher than or equivalent to vitamin C in theDPPH assay, and compounds 1, 3, 4, and 7-10 displayed higher antioxidant activity than vitamin C in the ORACassay. Compounds 1, 2, and 10 also exhibited stronger inhibitory effects on NO production than resveratrol.