Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii

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• 作者：Jin-Long Li ; Zhao-Bing Gao ; Wei-Min Zhao
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：January 22, 2016
• 年：2016
• 卷：79
• 期：1
• 页码：89-97
• 全文大小：359K
• ISSN：1520-6025

文摘

Nine new C₂₁ steroidal glycosides, named cynawilfosides A–I (1–9), along with 12 known compounds were isolated from the roots of Cynanchum wilfordii. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The five major components, cynawilfoside A (1), cynauricoside A (11), wilfoside C1N (16), wilfoside K1N (17), and cyanoauriculoside G (18), exhibited significant protection activity in a maximal electroshock (MES)-induced mouse seizure model with ED₅₀ values of 48.5, 95.3, 124.1, 72.3, and 88.1 mg/kg, respectively.