A General Synthesis of Ynones from Aldehydes via Oxidative C鈥揅 bond Cleavage under Aerobic Conditions

详细信息    查看全文

• 作者：Zhaofeng Wang ; Li Li ; Yong Huang
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：September 3, 2014
• 年：2014
• 卷：136
• 期：35
• 页码：12233-12236
• 全文大小：291K
• ISSN：1520-5126

文摘

We describe a direct synthesis of various ynones from readily available aldehydes and hypervalent alkynyl iodides. In this method, a gold catalyst and a secondary amine work synergistically to produce the trisubstituted allenyl aldehyde, which can be converted to the desired ynone through an in situ C鈥揅 bond oxidative cleavage using molecular oxygen.