文摘
The interparticle spacing of the surface-enhanced Raman scattering (SERS) substrate has a strong relationship with its enhancement factor (EF). How to precisely adjust the interparticle gap and generate SERS substrates with excellent quality and high reliability by a facile way is still a challenge. Here, we propose a convenient and environmentally friendly method to synthesize large-area Ag SERS substrates composed of either monodisperse nanoparticles (NPs), NP-linked nanowires (NWs), NW-weaved mesoporous membrane, or NP-aggregates by simply controlling the pH value in alkaline glucose solution, and their SERS enhancements have been evaluated. In addition, the EF of the Au NW-weaved film substrate prepared by our method is one order higher than that well-known dealloyed Au nanoporous substrate. Finally, the SERS spectrum of yeast at the single cell level is successfully acquired by using the highest EF substrate composed of monodisperse Ag NPs (8.24 脳 107) in this work at a very low laser power (0.17 mW).