New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes

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• 作者：Yatao Qiu ; Yanghan Liu ; Kai Yang ; Wenkun Hong ; Zheng Li ; Zhaoyang Wang ; Zhiyi Yao ; Sheng Jiang
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：July 15, 2011
• 年：2011
• 卷：13
• 期：14
• 页码：3556-3559
• 全文大小：774K
• 年卷期：v.13,no.14(July 15, 2011)
• ISSN：1523-7052

文摘

Several ligands were designed to promote transition-metal-free cross-coupling reactions of aryl halides with benzene derivatives. Among the systems probed, quinoline-1-amino-2-carboxylic acid was found to serve as an excellent catalyst for cross-coupling between aryl halides and unactivated benzene. Reactions using this inexpensive catalytic system displayed a high functional group tolerance as well as excellent chemoselectivities.