Protecting-Group-Free Total Synthesis of Aplykurodinone-1

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• 作者：Yu Tang ; Ji-tian Liu ; Ping Chen ; Ming-can Lv ; Zhen-zhen Wang ; Yi-kun Huang
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：December 5, 2014
• 年：2014
• 卷：79
• 期：23
• 页码：11729-11734
• 全文大小：388K
• ISSN：1520-6904

文摘

A concise, stereoselective, and protecting-group-free total synthesis of aplykurodinone-1 from Hajos鈥揚arrish ketone was described. The synthetic approach features a sequence of aerobic allylic oxidation and elimination of alcohol 9. The key intermediate for this synthesis was formed by a stereoselective intramolecular radical cyclization.