Copper Catalyzed Enantioselective Alkylation of Pyrrole with 尾,纬-Unsaturated 伪-Ketoesters: Application to One-Pot Construction of the Seven-Membered Ring by Merging a Gold Catalysis

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• 作者：Yanbin Hu ; Yanan Li ; Sheng Zhang ; Chong Li ; Lijun Li ; Zhenggen Zha ; Zhiyong Wang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：17
• 期：16
• 页码：4018-4021
• 全文大小：359K
• ISSN：1523-7052

文摘

A highly enantioselective Friedel鈥揅rafts alkylation of pyrrole to 尾,纬-unsaturated 伪-ketoesters was developed by virtue of a chiral copper complex, affording the alkylated derivatives of pyrrole with good yields and excellent enantioselectivities. Moreover, merging copper catalysis with gold catalysis realized a one-pot construction of the seven-membered ring to give annulated pyrroles with moderate to good yields and high enantiomeric excesses.