Chemoselective Transfer Hydrogenation of 伪,尾-Unsaturated Ketones Catalyzed by Pincer-Pd Complexes Using Alcohol as a Hydrogen Source

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• 作者：Boqiang Ding ; Zhenfeng Zhang ; Yangang Liu ; Masashi Sugiya ; Tsuneo Imamoto ; Wanbin Zhang
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3690-3693
• 全文大小：228K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

A pincer-Pd complex was utilized in the chemoselective transfer hydrogenation of 伪,尾-unsaturated ketones using n-BuOH as a hydrogen source and solvent. Good to excellent yields were obtained for various substrates even with reducible groups. Based on deuterium-labeling experiments, the reaction mechanism is proposed to occur via a pincer-Pd-hydride intermediate.