Microwave-Assisted Combinatorial Synthesis of New 3-Pyrimidin-5-ylpropanamides via a Solvent-Dependent Chemoselective Reaction

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• 作者：Wen-Juan Hao^† ; ; Bo Jiang^† ; ^&#8225 ; ; Shu-Jiang Tu*^† ; ^&#8225 ; ; Shan-Shan Wu^† ; ; Zheng-Guo Han^† ; ; Xu-Don
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2009
• 出版时间：March 9, 2009
• 年：2009
• 卷：11
• 期：2
• 页码：310-314
• 全文大小：213K
• 年卷期：v.11,no.2(March 9, 2009)
• ISSN：1520-4774

文摘

A series of new 3-pyrimidin-5-ylpropanamides was selectively synthesized via a microwave-assisted, chemoselective reaction of arylidene-Meldrum’s acid, 6-hydroxypyrimidin-4(3H)-one, and structurally diverse amines including (S or R)-1-phenylethanamine, cyclohexanamine, and cyclopentanamine depended on nature of solvents. In this reaction, the utilization of HOAc as a solvent leads to 3-pyrimidin-5-ylpropanamides, whereas water as reaction media results in the spiro[5.5]undecane-1,5,9-triones from same starting materials. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.