Phosphine-Catalyzed Cascade [3 + 2] Cyclization鈭扐llylic Alkylation, [2 + 2 + 1] Annulation, and [3 + 2] Cyclization Reactions between Allylic Carbonates and Enones

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• 作者：Rong Zhou ; Jianfang Wang ; Haibin Song ; Zhengjie He
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：February 18, 2011
• 年：2011
• 卷：13
• 期：4
• 页码：580-583
• 全文大小：747K
• 年卷期：v.13,no.4(February 18, 2011)
• ISSN：1523-7052

文摘

The phosphine-catalyzed annulations between Morita鈭払aylis鈭扝illman adduct carbonates and enones are reported. Under the catalysis of PBu₃ (20 mol %), cascade [3 + 2] cyclization鈭抋llylic alkylation, [2 + 2 + 1] annulation, and [3 + 2] cyclization reactions chemoselectively occur depending on the substituent variation of both the carbonate and enone. These reactions provide efficient syntheses of highly functionalized cyclopentenes and cyclopentanes.