FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

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• 作者：Chenjie Xu ; Zhenglong Yuan ; Nathan Kohler ; Jaemin Kim ; Maureen A. Chung ; Shouheng Sun
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：October 28, 2009
• 年：2009
• 卷：131
• 期：42
• 页码：15346-15351
• 全文大小：343K
• 年卷期：v.131,no.42(October 28, 2009)
• ISSN：1520-5126

文摘

Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H₂O₂ decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy.