A Zn2+ Fluorescent Sensor Derived from 2-(Pyridin-2-yl)benzoimidazole with Ratiometric Sensing Potential
详细信息 查看全文
- 作者：Zhipeng Liu† ; ; Changli Zhang† ; § ; ; Yunling Li† ; ; Zhengyi Wu† ; ; Fang Qian† ; ; Xiaoliang Yang† ;
- 刊名：Organic Letters
- 出版年：2009
- 出版时间：February 19, 2009
- 年：2009
- 卷：11
- 期：4
- 页码：795-798
- 全文大小：185K
- 年卷期：v.11,no.4(February 19, 2009)
- ISSN：1523-7052
文摘
A fluorescent Zn2+ sensor based on the 2-(2′-pyridinyl)benzoimidazole (2-PBI) fluorophore has been devised by incorporation with a Zn2+ ionophore, bis(pyridin-2-ylmethyl)amine. The sensor (PBITA) demonstrates a Zn2+-specific emission shift and enhancement with a 1:1 binding ratio. Due to the Zn2+-induced coplanation of 2-PBI via reversion/rotation, PBITA is shown to behave as a ratiometric sensor. The intracellular Zn2+ imaging ability of the sensor has been tested in HeLa cells using a confocal microscope.