Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor

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• 作者：Jacob J. Day ; Zhenhua Yang ; Wei Chen ; Armando Pacheco ; Ming Xian
• 刊名：ACS Chemical Biology
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：11
• 期：6
• 页码：1647-1651
• 全文大小：298K
• 年卷期：0
• ISSN：1554-8937

文摘

Sulfur dioxide (SO₂) has long been considered a toxic environmental pollutant and byproduct of industrial processing. Recently it has become evident that SO₂ may also have regulatory functions in mammalian pulmonary systems. However, the study of these effects has proven to be challenging due to the difficulty in administering SO₂ in a reliable manner. In this work, we report the discovery of a new pH-dependent and water-soluble SO₂ donor, benzothiazole sulfinate (BTS). We have found BTS to have slow and sustained SO₂ release at physiological pH. Additionally, we have explored its vasorelaxation properties as compared to the authentic SO₂ gas solutions. The slow release of BTS should make it a useful tool for the study of endogenously generated SO₂.