文摘
Kilogram-scale synthesis of a bioactive pentapeptide in solution by 鈥? + 2鈥?fragment coupling strategy has been successively accomplished in the development of OGP (10鈥?4), a minimal OGP-derived sequence that retains the full proliferative activity of the osteogenic growth peptide. The synthetic scheme, coupling conditions, and scaling-up of the process are systematically studied; the epimerization of the tripeptide fragment and pentapeptide are also evaluated.