Silica Gel-Promoted Tandem Addition−Cyclization Reactions of 2-Alkynylbenzenamines with Isothiocyanates

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• 作者：Qiuping Ding ; Banpeng Cao ; Zhenzhen Zong ; Yiyuan Peng
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2010
• 出版时间：May 10, 2010
• 年：2010
• 卷：12
• 期：3
• 页码：370-373
• 全文大小：137K
• 年卷期：v.12,no.3(May 10, 2010)
• ISSN：1520-4774

文摘

Tandem addition−cyclization reactions of 2-alkynylbenzenamines with isothiocyanates promoted by silica gel are described. This reaction proceeds smoothly at 80 °C under metal- and solvent-free conditions, which provides an efficient and practical route for the generation of 2,4-dihydro-1H-benzo[d][1,3]thiazines. The recovered silica gel could be reused for several times.