Phase Equilibria for the Glycine鈥揗ethanol鈥揘H4Cl鈥揌2O System
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- 作者：Yan Zeng ; Zhibao Li ; George P. Demopoulos
- 刊名：Industrial & Engineering Chemistry Research
- 出版年：2014
- 出版时间：October 29, 2014
- 年：2014
- 卷：53
- 期：43
- 页码：16864-16872
- 全文大小：511K
- ISSN：1520-5045
文摘
An investigation of the phase equilibria of the glycine鈥搈ethanol鈥揘H4Cl鈥揌2O system was carried out with the objective of optimizing the monochloroacetic acid (MCA) process for the production of glycine. Phase equilibrium of the glycine鈥揘H4Cl鈥揌2O system at temperatures over the range of 283.2鈥?53.2 K was determined for concentrations ranging up to the multiple saturation points. The solubilities of both glycine and NH4Cl were found to increase with increasing temperature, as well as with increasing concentration of other solutes. The Bromley鈥揨emaitis model for ions and the Pitzer formulation for glycine neutral species implemented in the OLI platform were used in the regression of the experimental solubilities. The average absolute deviations between the regressed solubility values and the experimental data were found to be 1.4% for glycine and 0.93% for NH4Cl. Three binary interaction parameters of the Pitzer formulation were newly obtained and coupled with the Bromley鈥揨emaitis parameters documented in OLI鈥檚 databank to predict the multiple saturation points of the system. Additionally, the solubility of glycine in methanol鈥揌2O mixtures was also measured from 283.2 to 323.2 K, and a sharp decline was observed as a function of the content of methanol. Such thermodynamic information is definitely useful for improving the existing industrial process, as well as providing fundamentals for the development of new glycine production processes.