A Water-Soluble Bis(thiosemicarbazone) Ligand. A Sensitive Probe and Metal Buffer for Zinc

详细信息    查看全文

• 作者：Gojko Buncic ; Paul S. Donnelly ; Brett M. Paterson ; Jonathan M. White ; Matthias Zimmermann ; Zhiguang Xiao ; Anthony G. Wedd
• 刊名：Inorganic Chemistry
• 出版年：2010
• 出版时间：April 5, 2010
• 年：2010
• 卷：49
• 期：7
• 页码：3071-3073
• 全文大小：682K
• 年卷期：v.49,no.7(April 5, 2010)
• ISSN：1520-510X

文摘

The first member of a water-soluble family of bis(thiosemicarbazone) ligands is reported. It forms a 1:1 complex with Zn^II that absorbs intensely in the visible region (λ_max = 414 nm; ε = 1.8(4) × 10⁴ M⁻¹ cm⁻¹; pH 7.3). Its affinity for Zn^II (K_D = 5.9(3) × 10⁻⁹ M at pH 7.3) was determined by competition with ligand ethylene glycol O,O′-bis(2-aminoethyl)-N,N,N′,N′-tetraacetic acid. Its potential application as a chromophoric probe was demonstrated by estimation of the Zn^II binding affinities of the soluble metal-binding domains of two plant metal-transporting proteins.