Solvent-Free Cross-Dehydrogenative Coupling Reactions under High Speed Ball-Milling Conditions Applied to the Synthesis of Functionalized Tetrahydroisoquinolines

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• 作者：Weike Su ; Jingbo Yu ; Zhenhua Li ; Zhijiang Jiang
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：76
• 期：21
• 页码：9144-9150
• 全文大小：301K
• 年卷期：v.76,no.21(November 4, 2011)
• ISSN：1520-6904

文摘

Solvent-free reaction using a high-speed ball milling technique has been first applied to cross-dehydrogenative coupling (CDC) reactions between tetrahydroisoquinolines and three types of pronucleophiles such as nitroalkanes, alkynes, and indoles. All coupling products were obtained in good yields at short reaction times (no more than 40 min). When alkynes and indoles were used as pronucleophile, the reactions can be catalyzed efficiently by recoverable copper balls without any additional metal catalyst.