Using -Lactamase to Trigger Supramolecular Hydrogelation
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- 作者：Zhimou Yang ; Pak-Leung Ho ; Gaolin Liang ; Kin Hung Chow ; Qigang Wang ; Yang Cao ; Zhihong Guo ; Bing Xu
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：January 17, 2007
- 年：2007
- 卷：129
- 期：2
- 页码：266 - 267
- 全文大小：137K
- 年卷期：v.129,no.2(January 17, 2007)
- ISSN：1520-5126
文摘
This paper reports the rational design and synthesis of a 
-lactam conjugate. Treating the conjugate with -lactamase cleaves the scissile -lactam amide bond, releases a hydrogelator, and results in enzymatic formation of a supramolecular hydrogel. The process involves the use of a bacterial enzyme-the one causes antibiotic inactivation and accounts for resistance to -lactams in many clinical important pathogens-to catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymatic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications.
-lactam conjugate. Treating the conjugate with -lactamase cleaves the scissile -lactam amide bond, releases a hydrogelator, and results in enzymatic formation of a supramolecular hydrogel. The process involves the use of a bacterial enzyme-the one causes antibiotic inactivation and accounts for resistance to -lactams in many clinical important pathogens-to catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymatic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications.